Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
نویسندگان
چکیده
Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-the-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance.
منابع مشابه
The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review
Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most promine...
متن کاملThe recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review
Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most promine...
متن کاملP 62: Markers of Neuroinflammation Related to Alzheimer\'s Disease Pathology in the Elderly
Alzheimer Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. In vitro and animal studies have linked neuroinflammation to Alzheimer's disease (AD) pathology. Studies on marke...
متن کاملتاثیر تمرینات ایروبیک، ایروبیک در آب و تمرین در آب بر حافظه کاری زنان سالمند مبتلا به آلزایمر
Introduction and purpose: Physical inactivity is an important risk factor for cognitive decline in ageing and for Alzheimer’s disease. The aim of this study was to investigate The effect of Aerobic in water and Exercises in water on working memory in elderly women with Alzheimer's disease. Material and Methods: This study was a quasi-experimental study. The statistical community consiste...
متن کاملCognitive Rehabilitation An Effective Intervention to Decrease the Cognitive Deficits in Older Adults With Alzheimer Disease
Objectives: The aim of present study was to investigate the effect of cognitive rehabilitation, a new and non-pharmacological approach to reduce memory and other cognitive deficits in Alzheimer's disease. Methods & Materials: This study was a quasi-experimental research, in singlesubject study-with control group- and based on an A-B design. That was conducted in two groups of control and exp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Alzheimer's & Dementia
دوره 12 شماره
صفحات -
تاریخ انتشار 2016